Air: 
Eagle Crest-Hudson Airport , Milton, DE  (non-commercial),  6 miles fr0m Lewes
Salisbury Regional Airport, Salisbury, MD, 45 miles from Lewes
Delaware Coastal Airport|Sussex County Airport, Georgetown, DE, commercial and air freight, 15 miles from Lewes
Wilmington (DE) Airport, Wilmington, DE, 89  miles from Lewes
Baltimore-Washington International Thurgood Marshall Airport, Baltimore, MD, 110 miles from Lewes
Reagan National AIrport, Arlington, VA (DC Suburb), 121 miles from Lewes
Philadelphia International Airport, Philadelphia, PA 120 miles from Lewes

Bus:
DART First State, 1-800-652-DART
       Paratransit (shuttle service), 1-800-553-3278
Lewes Bus (shuttle service to Philadelphia Airport), 302-470-6784

Ferry:  Cape May-Lewes Ferry, 800-743-3779

Rail:    Amtrak, Wilmington, DE, 1-800-872-7245

Shuttle: Jolly Trolley, 302-644-0400

Water Taxi :  Cape Water Taxi & Tours, 302-644-7334