Air: 
Eagle Crest-Hudson Airport , Milton, DE  (non-commercial),  6 miles fr0m Lewes
Salisbury Regional Airport, Salisbury, MD, 45 miles from Lewes
Delaware Coastal Airport|Sussex County Airport, Georgetown, DE, commercial and air freight, 15 miles from Lewes
Wilmington (DE) Airport, Wilmington, DE , new service, 89  miles from Lewes
Baltimore-Washington International Thurgood Marshall Airport, Baltimore, MD, 110 miles from Lewes
Reagan National AIrport, Arlington, VA (DC Suburb), 121 miles from Lewes
Philadelphia International Airport, Philadelphia, PA 120 miles from Lewes

Bus:   DART First State, 1-800-652-DART
Paratransit (shuttle service), 1-800-553-3278

Ferry:  Cape May-Lewes Ferry, 800-743-3779

Rail:    Amtrak, Wilmington, DE, 1-800-872-7245

Shuttle: Jolly Trolley, 302-227-1197

Water Taxi :  Cape Water Taxi & Tours, 302-644-7334